Bingchen Yu lab at GSU is committed to advancing the study of signal transduction and medicine by focusing on the complex area of protein-biomolecule interactions. Proteins interact with proteins, carbohydrates, nucleic acids, and lipids. These interactions govern every aspect of life. Deciphering these interactions can contribute to the understanding of the fundamental aspects of life and open up diverse opportunities for therapeutic intervention. Additionally, the modulation of protein-biomolecule interactions such as protein-protein interactions (PPIs) represents a promising frontier in drug discovery, as it allows the targeting of "undruggable" proteins with flat surfaces.

Our lab is dedicated to developing innovative chemical tools that can covalently capture the transient and reversible protein-biomolecule interactions. To achieve this, we employ a multi-disciplinary approach that integrates organic synthesis, molecular biology, and protein engineering. By combining these techniques, we aim to gain a better understanding of the roles that protein-biomolecule interactions play in disease progression, and ultimately facilitate the discovery of new drugs that target protein-biomolecule interactions.